Interaction of V-type ATPase inhibitors and extracellular NAADP-triggered calcium release in skeletal muscle cells
نویسندگان
چکیده
Background Nicotinic acid adenine dinucleotide phosphate (NAADP) has been identified as a calcium-mobilizing second messenger. NAADP is regularly enzymatically synthesized by ADP-ribosyl cyclases, in particular under acidic conditions. In nanomolar concentrations NAADP targets selectively the ryanodine receptor type 1 on the sarcoplasmic reticulum, and the two pore channels localized in dense-core secretory vesicles and lysosomes.
منابع مشابه
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011